Alchemy - Rate 3

As i promised, i also did some rate 3 alchemies to see, is it worth to pay for the +1 rate to get rate 4, or not? In my oponion it's worth to pay, since i get more materials from the crafting ones, however nowadays they don't have that high value, so you can decide it by yourself going through the table:

The only thing why rate 3 is better than rate 4 is the Sedatives, becaouse you can get them in bulks from rate 3 and you can't get any in rate 4, so if you'd like to stock up with them, rate 3 is better for you.